Publications

Ling Zhong, Zhenzhen Yan, Dexiang Jiang, Kuo-Chan Weng, Yue Ouyang, Hangyu Zhang, Xiaoqing Lin, Chenxin Xiao, Huaiyu Yang, Jing Yao, Xinjiang Kang, Changhe Wang, Chen Huang, Bing Shen, Sookja Kim Chung, Zhi-Hong Jiang, Wandi Zhu, Erwin Neher, Jonathan R Silva, Panpan Hou (2024). Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants. Circulation Research.

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Max Homilius#, Wandi Zhu#, Samuel S Eddy, Patrick C Thompson, Huahua Zheng, Caleb N Warren, Chiara G Evans, David D Kim, Lucius L Xuan, Cissy Nsubuga, Zachary Strecker, Christopher J Pettit, Jungwoo Cho, Mikayla N Howie, Alexandra S Thaler, Evan Wilson, Bruce Wollison, Courtney Smith, Julia B Nascimben, Diana N Nascimben, Gabriella M Lunati, Hassan C Folks, Matthew Cupelo, Suriya Sridaran, Carolyn Rheinstein, Taylor Mcclennen, Shinichi Goto, James G Truslow, Sara Vandenwijngaert, Calum a MacRae#, Rahul C Deo# (2023). Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases. Nature Genetics #co-corresponding authors.

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Peinan Hu, Bingqi Wang, Dongxu Jin, Yedan Gu, Hongyang He, Xiangli Meng, Wandi Zhu, David Y Chiang, Weiming Li, Calum a MacRae, Yao Zu (2023). Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification. Cellular and Molecular Life Sciences.

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Zhenzhen Yan, Ling Zhong, Wandi Zhu, Sookja Kim Chung, Panpan Hou (2023). Chinese herbal medicine for the treatment of cardiovascular diseases ─ Targeting cardiac ion channels. Pharmacological Research.

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Wandi Zhu, Rahul C Deo, Calum a MacRae (2022). Single Cell Biology: Exploring Somatic Cell Behaviors, Competition and Selection in Chronic Disease. Frontiers in Pharmacology.

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Wandi Zhu#, Shihui Guo, Max Homilius, Cissy Nsubuga, Shane H Wright, Dajun Quan, Ashmita KC, Samuel S Eddy, Rachelle a Victorio, Manu Beerens, Robert Flaumenhaft, Rahul C Deo, Calum a MacRae# (2022). PIEZO1 mediates a mechanothrombotic pathway in diabetes. Science Translational Medicine #Corresponding authors.

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Wandi Zhu, Wei Wang, Paweorn Angsutararux, Rebecca L Mellor, Lori L Isom, Jeanne M Nerbonne, Jonathan R Silva (2021). Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits. JCI Insight.

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Paweorn Angsutararux, Po Wei Kang, Wandi Zhu, Jonathan R Silva (2021). Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation. Journal of General Physiology.

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Paweorn Angsutararux, Wandi Zhu, Taylor L Voelker, Jonathan R Silva (2021). Molecular pathology of sodium channel beta-subunit variants. Frontiers in Pharmacology.

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Wandi Zhu#, Tianbo Li, Jonathan R. Silva, Jun Chen# (2020). Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms. Scientific Reports #Corresponding authors.

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Samantha C Salvage, Wandi Zhu, Zaki F Habib, Soyon S Hwang, Jennifer R Irons, Christopher L H Huang, Jonathan R Silva, Antony P Jackson (2019). Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain. *Journal of Biological Chemistry *.

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Wandi Zhu, Andrea Mazzanti, Taylor L. Voelker, Panpan Hou, Jonathan D. Moreno, Paweorn Angsutararux, Kristen M. Naegle, Silvia G. Priori, Jonathan R. Silva (2019). Predicting patient response to the antiarrhythmic mexiletine based on genetic variation: Personalized medicine for long QT syndrome. Circulation Research.

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Jonathan D. Moreno, Wandi Zhu, Kathryn Mangold, Woenho Chung, Jonathan R. Silva (2019). A Molecularly Detailed NaV1.5 Model Reveals a New Class I Antiarrhythmic Target. JACC: Basic to Translational Science.

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Kathryn E Mangold, Brittany D Brumback, Paweorn Angsutararux, Taylor L Voelker, Wandi Zhu, Po Wei Kang, Jonathan D Moreno, Jonathan R Silva (2017). Mechanisms and models of cardiac sodium channel inactivation. Channels.

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Wandi Zhu, Taylor L Voelker, Zoltan Varga, Angela R Schubert, Jeanne M Nerbonne, Jonathan R Silva (2017). Mechanisms of noncovalent β subunit regulation of NaV channel gating. The Journal of General Physiology.

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Eric J Hsu, Wandi Zhu, Angela R Schubert, Taylor Voelker, Zoltan Varga, Jonathan R Silva (2017). Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains. The Journal of General Physiology.

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Colin H. Peters, Alec Yu, Wandi Zhu, Jonathan R. Silva, Peter C. Ruben (2017). Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation. PLoS ONE.

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Wandi Zhu, Zoltan Varga, Jonathan R Silva (2016). Molecular motions that shape the cardiac action potential : Insights from voltage clamp fl uorometry. Progress in Biophysics and Molecular Biology.

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Hong-Gang Wang, Wandi Zhu, Ronald J Kanter, Jonathan R Silva, Christina Honeywell, Robert M Gow, Geoffrey S Pitt (2016). A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias. Journal of Molecular and Cellular Cardiology.

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Zoltan Varga, Wandi Zhu, Angela R Schubert, Jennifer L Pardieck, Arie Krumholz, Eric J Hsu, Mark a Zaydman, Jianmin Cui, Jonathan R Silva (2015). Direct measurement of cardiac Na+ channel conformations reveals molecular pathologies of inherited mutations. Circulation: Arrhythmia and Electrophysiology.

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Sheena Claire Li, Theodore T Diakov, Tao Xu, Maureen Tarsio, Wandi Zhu, Sergio Couoh-Cardel, Lois S Weisman, Patricia M Kane (2014). The signaling lipid PI(3,5)P2 stabilizes V1–Vo sector interactions and activates the V-ATPase. Molecular Biology of the Cell.

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