Zhu Lab
Zhu Lab
People
Publications
Join
Article-Journal
Targeting the IKs Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants
Ling Zhong
,
Zhenzhen Yan
,
Dexiang Jiang
,
Kuo-Chan Weng
,
Yue Ouyang
,
Hangyu Zhang
,
Xiaoqing Lin
,
Chenxin Xiao
,
Huaiyu Yang
,
Jing Yao
,
Xinjiang Kang
,
Changhe Wang
,
Chen Huang
,
Bing Shen
,
Sookja Kim Chung
,
Zhi-Hong Jiang
,
Wandi Zhu
,
Erwin Neher
,
Jonathan R Silva
,
Panpan Hou
Cite
DOI
URL
Chinese herbal medicine for the treatment of cardiovascular diseases ─ Targeting cardiac ion channels
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality, imposing an increasing global health burden. Cardiac …
Zhenzhen Yan
,
Ling Zhong
,
Wandi Zhu
,
Sookja Kim Chung
,
Panpan Hou
Cite
DOI
URL
Modeling of large-scale hoxbb cluster deletions in zebrafish uncovers a role for segmentation pathways in atrioventricular boundary specification
Hox genes orchestrate the segmental specification of the muscular circulatory system in invertebrates but it has not proven …
Peinan Hu
,
Bingqi Wang
,
Dongxu Jin
,
Yedan Gu
,
Hongyang He
,
Xiangli Meng
,
Wandi Zhu
,
David Y Chiang
,
Weiming Li
,
Calum a MacRae
,
Yao Zu
Cite
DOI
URL
Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases
Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying …
Max Homilius#
,
Wandi Zhu#
,
Samuel S Eddy
,
Patrick C Thompson
,
Huahua Zheng
,
Caleb N Warren
,
Chiara G Evans
,
David D Kim
,
Lucius L Xuan
,
Cissy Nsubuga
,
Zachary Strecker
,
Christopher J Pettit
,
Jungwoo Cho
,
Mikayla N Howie
,
Alexandra S Thaler
,
Evan Wilson
,
Bruce Wollison
,
Courtney Smith
,
Julia B Nascimben
,
Diana N Nascimben
,
Gabriella M Lunati
,
Hassan C Folks
,
Matthew Cupelo
,
Suriya Sridaran
,
Carolyn Rheinstein
,
Taylor Mcclennen
,
Shinichi Goto
,
James G Truslow
,
Sara Vandenwijngaert
,
Calum a MacRae#
,
Rahul C Deo#
Cite
DOI
URL
PIEZO1 mediates a mechanothrombotic pathway in diabetes
Hematopoietic cell selection based on PIEZO1 expression drives thrombosis risk in type 2 diabetes. Patients with diabetes are at …
Wandi Zhu#
,
Shihui Guo
,
Max Homilius
,
Cissy Nsubuga
,
Shane H Wright
,
Dajun Quan
,
Ashmita KC
,
Samuel S Eddy
,
Rachelle a Victorio
,
Manu Beerens
,
Robert Flaumenhaft
,
Rahul C Deo
,
Calum a MacRae#
Cite
DOI
URL
Single Cell Biology: Exploring Somatic Cell Behaviors, Competition and Selection in Chronic Disease
The full range of cell functions is under-determined in most human diseases. The evidence that somatic cell competition and clonal …
Wandi Zhu
,
Rahul C Deo
,
Calum a MacRae
Cite
URL
Conformations of voltage-sensing domain III differentially define NaV channel closed- and open-state inactivation
Voltage-gated Na+ (NaV) channels underlie the initiation and propagation of action potentials (APs). Rapid inactivation after NaV …
Paweorn Angsutararux
,
Po Wei Kang
,
Wandi Zhu
,
Jonathan R Silva
Cite
DOI
URL
Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits
Native myocardial voltage-gated sodium (NaV) channels function in macromolecular complexes comprising a pore-forming (α) subunit and …
Wandi Zhu
,
Wei Wang
,
Paweorn Angsutararux
,
Rebecca L Mellor
,
Lori L Isom
,
Jeanne M Nerbonne
,
Jonathan R Silva
Cite
DOI
URL
Molecular pathology of sodium channel beta-subunit variants
Paweorn Angsutararux
,
Wandi Zhu
,
Taylor L Voelker
,
Jonathan R Silva
Cite
Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms
Voltage-gated Na+ (NaV) channels regulate homeostasis in bacteria and control membrane electrical excitability in mammals. Compared to …
Wandi Zhu#
,
Tianbo Li
,
Jonathan R. Silva
,
Jun Chen#
Cite
DOI
»
Cite
×